Article

<i>XPOT</i> Deficiency causes a human disorder through impaired tRNA nuclear export

2026-02-04

Abstract excerpt

<h4>Background</h4> The transport of transfer RNAs (tRNAs) from the nucleus to the cytoplasm is a crucial step in the regulation of gene expression and protein synthesis. This process is mediated by specialized export molecules, among which XPOT (Exportin-t, XPO3) plays a central role by recognizing and transporting mature tRNAs through the nuclear pore complex. XPOT is not essential in RNA trafficking in the sim...

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Literature Corpus work: 8e3e7f9d-16ea-5d8b-a190-84c1831210f3
DOI: 10.64898/2026.01.28.26344748

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