Article
Heteromeric co-assembly of two insect nicotinic acetylcholine receptor alpha subunits: influence on sensitivity to neonicotinoid insecticides.
Journal of neurochemistry - 1 Jan 2009
Liu Zewen, Han Zhaojun, Zhang Yixi, Song Feng, Yao Xiangmei, Liu Shuhua, Gu Jianhua, Millar Neil S
Abstract excerpt
Neonicotinoid insecticides, such as imidacloprid, are selective agonists of insect nicotinic acetylcholine receptors (nAChRs) and are used extensively in areas of crop protection and animal health to control a variety of insect pest species. Here, we describe studies performed with nAChR subunits Nlalpha1 and Nlalpha2 cloned from the brown planthopper Nilaparvata lugens, a major insect pest of rice crops in many...
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