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Article

Combinatorial mutations in loops D and F strongly influence responses of the alpha7 nicotinic acetylcholine receptor to imidacloprid.

Brain research - 21 Nov 2003

Shimomura Masaru, Yokota Maiko, Okumura Masako, Matsuda Kazuhiko, Akamatsu Miki, Sattelle David B, Komai Koichiro

Abstract excerpt

The nitro group of a neonicotinoid, imidacloprid, plays a key role in its selective actions on insect nicotinic acetylcholine receptors (nicotinic AChRs) and is postulated to bind close to residues Q79 in loop D and G189 in loop F of the chicken alpha7 nicotinic AChR. To evaluate the relative contributions of these residues to interactions with imidacloprid, Q79 and G189 were replaced in tandem by first basic...

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Share to alpha7 Nicotinic Acetylcholine Receptor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14575878
DOI: 10.1016/j.brainres.2003.08.005

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