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Article

Combined roles of loops C and D in the interactions of a neonicotinoid insecticide imidacloprid with the alpha4beta2 nicotinic acetylcholine receptor.

Neuropharmacology - 1 Jan 2009

Toshima Kayoko, Kanaoka Satoshi, Yamada Atsushi, Tarumoto Kiyoshi, Akamatsu Miki, Sattelle David B, Matsuda Kazuhiko

Abstract excerpt

Neonicotinoid insecticides are widely used for crop protection based on their selective actions on insect nicotinic acetylcholine receptors (insect nAChRs). Loops C and D in insect nAChRs have been shown to possess structural features favorable for neonicotinoid-nAChR interactions. However, it remains to be resolved whether such features serve either co-operatively, or independently, to enhance neonicotinoid...

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PMID: 18790701
DOI: 10.1016/j.neuropharm.2008.08.022

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