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Article

The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests.

Scientific reports - 5 May 2020

Shimada Shota, Kamiya Masaki, Shigetou Sho, Tomiyama Kakeru, Komori Yuma, Magara Leo, Ihara Makoto, Matsuda Kazuhiko

Abstract excerpt

Neonicotinoids selectively modulate insect nicotinic acetylcholine receptors (insect nAChRs). Studies have shown that serine with ability to form a hydrogen bond in loop C of some insect nAChR α subunits and glutamate with a negative charge at the corresponding position in vertebrate nAChRs may contribute to enhancing and reducing the neonicotinoid actions, respectively. However, there is no clear evidence what...

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Identifiers

PMID: 32371996
DOI: 10.1038/s41598-020-64258-z
PMCID: PMC7200709

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