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Article

Modulation of recombinant, α2, α3 or α4*-nicotinic acetylcholine receptor (nAChR) function by nAChR β3 subunits.

Journal of neurochemistry - 1 May 2012

Dash Bhagirathi, Bhakta Minoti, Chang Yongchang, Lukas Ronald J

Abstract excerpt

The nicotinic acetylcholine receptor (nAChR) β3 subunit is thought to serve an accessory role in nAChR subtypes expressed in dopaminergic regions implicated in drug dependence and reward. When β3 subunits are expressed in excess, they have a dominant-negative effect on function of selected nAChR subtypes. In this study, we show, in Xenopus oocytes expressing α2, α3 or α4 plus either β2 or β4 subunits, that in the...

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Identifiers

PMID: 22309577
DOI: 10.1111/j.1471-4159.2012.07685.x
PMCID: PMC3569009

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