Article
Imidacloprid acts as an antagonist on insect nicotinic acetylcholine receptor containing the Y151M mutation.
Neuroscience letters - 3 Dec 2008
Zhang Yixi, Liu Shuhua, Gu Jianhua, Song Feng, Yao Xiangmei, Liu Zewen
Abstract excerpt
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels which mediate fast cholinergic synaptic transmission in insect and vertebrate nervous systems. A point mutation Y151S had been identified in Nilaparvata lugens (brown planthopper) that is associated with target-site resistance to neonicotinoid insecticides. Methionine (M151) is found in the Caenorhabditis elegans alpha subunit acr18 at the...
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