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Article

High-resolution melting curve analysis of genomic and whole-genome amplified DNA.

Clinical chemistry - 1 Dec 2008

Cho Michael H, Ciulla Dawn, Klanderman Barbara J, Raby Benjamin A, Silverman Edwin K

Abstract excerpt

BACKGROUND: High-resolution melting curve analysis is an accurate method for mutation detection in genomic DNA. Few studies have compared the performance of high-resolution DNA melting curve analysis (HRM) in genomic and whole-genome amplified (WGA) DNA. METHODS: In 39 paired genomic and WGA samples, 23 amplicons from 9 genes were PCR amplified and analyzed by high-resolution melting curve analysis using the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19042988
DOI: 10.1373/clinchem.2008.109744
PMCID: PMC2755063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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