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Article

PIAS family in cancer: from basic mechanisms to clinical applications

25 Mar 2024

Abstract excerpt

Protein inhibitors of activated STATs (PIAS) are proteins for cytokine signaling that activate activator-mediated gene transcription. These proteins, as versatile cellular regulators, have been described as regulators of approximately 60 proteins. Dysregulation of PIAS is associated with inappropriate gene expression that promotes oncogenic signaling in multiple cancers. Multiple lines of evidence have revealed...

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PMID: 38590645
DOI: 10.3389/fonc.2024.1376633

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