Article
Pig skin includes dendritic cell subsets transcriptomically related to human CD1a and CD14 dendritic cells presenting different migrating behaviors and T cell activation capacities.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014
Marquet Florian, Vu Manh Thien-Phong, Maisonnasse Pauline, Elhmouzi-Younes Jamila, Urien Céline, Bouguyon Edwige, Jouneau Luc, Bourge Mickael, Simon Gaëlle, Ezquerra Angel, Lecardonnel Jérôme, Bonneau Michel, Dalod Marc, Schwartz-Cornil Isabelle, Bertho Nicolas
Abstract excerpt
Swine skin is one of the best structural models for human skin, widely used to probe drug transcutaneous passage and to test new skin vaccination devices. However, little is known about its composition in immune cells, and among them dendritic cells (DC), that are essential in the initiation of the immune response. After a first seminal work describing four different DC subpopulations in pig skin, we hereafter...
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