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Article

Heterogeneity of Phenotypic and Functional Changes to Porcine Monocyte-Derived Macrophages Triggered by Diverse Polarizing Factors In Vitro.

International journal of molecular sciences - 28 Feb 2023

Franzoni Giulia, Mura Lorena, Razzuoli Elisabetta, De Ciucis Chiara Grazia, Fruscione Floriana, Dell'Anno Filippo, Zinellu Susanna, Carta Tania, Anfossi Antonio G, Dei Giudici Silvia, Graham Simon P, Oggiano Annalisa

Abstract excerpt

Swine are attracting increasing attention as a biomedical model, due to many immunological similarities with humans. However, porcine macrophage polarization has not been extensively analyzed. Therefore, we investigated porcine monocyte-derived macrophages (moMΦ) triggered by either IFN-γ + LPS (classical activation) or by diverse "M2-related" polarizing factors: IL-4, IL-10, TGF-β, and dexamethasone. IFN-γ and...

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Identifiers

PMID: 36902099
DOI: 10.3390/ijms24054671
PMCID: PMC10003195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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