Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.

BMC cell biology - 26 Nov 2008

Wang Weiping, Brautigan David L

Abstract excerpt

BACKGROUND: Primary cilia are flagella-like projections from the centriole of mammalian cells that have a key role in cell signaling. Human diseases are linked to defects in primary cilia. Microtubules make up the axoneme of cilia and are selectively acetylated and this is thought to contribute to the stability of the structure. However, mechanisms to regulate tubulin acetylation in cilia are poorly understood....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cilia
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Microtubules

Share to Retina

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 19036150
DOI: 10.1186/1471-2121-9-62
PMCID: PMC2630314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.PMID 19036150Read ↗

Loss of Bbs8 leads to cystic kidney disease in mice with reduced acetylation of ciliary alpha-tubulin through HDAC2Semantic proximity Read ↗

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.Semantic proximity Read ↗

Hook2 is involved in the morphogenesis of the primary ciliumSemantic proximity Read ↗

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.Semantic proximity Read ↗

<i>Tet2</i> loss suppress α-synuclein pathology by stimulating ciliogenesisSemantic proximity Read ↗

Primary cilia promote resistance to EGFR tyrosine kinase inhibitor, osimertinib, in non–small cell lung cancerSemantic proximity Read ↗

Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettesSemantic proximity Read ↗

Restoring the Balance: CRISPRa-Driven β-Tubulin Compensation as a Strategy for Tubulinopathy Treatment.Semantic proximity Read ↗

⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis.Semantic proximity Read ↗

Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models.Semantic proximity Read ↗

PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.Semantic proximity Read ↗

αTAT1 is the major α-tubulin acetyltransferase in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.