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Article

Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2009

Cao Ying, Semanchik Nicole, Lee Seung Hun, Somlo Stefan, Barbano Paolo Emilio, Coifman Ronald, Sun Zhaoxia

Abstract excerpt

Polycystic kidney disease (PKD) is a common human genetic disease with severe medical consequences. Although it is appreciated that the cilium plays a central role in PKD, the underlying mechanism for PKD remains poorly understood and no effective treatment is available. In zebrafish, kidney cyst...

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Identifiers

PMID: 19966229
DOI: 10.1073/pnas.0911987106
PMCID: PMC2799791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19966229-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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