Article

<i>Tet2</i> loss suppress α-synuclein pathology by stimulating ciliogenesis

2024-08-06

Abstract excerpt

<h4>ABSTRACT</h4> There are no approved treatments that slow Parkinson’s disease (PD) progression and therefore it is important to identify novel pathogenic mechanisms that can be targeted. Loss of the epigenetic marker, Tet2 appears to have some beneficial effects in PD models, but the underlying mechanism of action is not well understood. We performed an unbiased transcriptomic analysis of cortical neurons iso...

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Literature Corpus work: 70325bf6-033f-54b9-a79b-58382c4af250
DOI: 10.1101/2024.08.02.606408

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