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Article

PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.

Developmental biology - 1 Sept 2017

Li Jia, Wang Chengbing, Wu Chuanqing, Cao Ting, Xu Guoqiang, Meng Qing, Wang Baolin

Abstract excerpt

Hedgehog (Hh) signaling is thought to occur in primary cilia, but the molecular basis of Gli2 and Gli3 activation by Hh signaling in cilia is unknown. Similarly, how ciliary gene mutations result in reduced Gli3 processing that generates a repressor is also not clear. Here we show that Hh signaling inhibits Gli2 and Gli3 phosphorylation by protein kinase A (PKA) in cilia. The cilia related gene Talpid3 (Ta3)...

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Identifiers

PMID: 28673820
DOI: 10.1016/j.ydbio.2017.06.035
PMCID: PMC5831674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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