Article
Quadruplex-duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association.
Biochemical and biophysical research communications - 4 Feb 2005
Halder Kangkan, Mathur Vidhi, Chugh Dipankar, Verma Anjali, Chowdhury Shantanu
Abstract excerpt
The nuclease hypersensitive element NHE III(I) is an important anti-cancer target as the transcription of oncogene c-myc is largely regulated by it. It has been postulated that regulatory control is mediated by G-quadruplex formation in the NHE anti-sense strand through a competition between the duplex and the quadruplex states. A mutation in the NHE has been implicated in cancer. In this study, the reported...
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