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Exploring G-quadruplex structure in <i>PRCC-TFE3</i> fusion Oncogene: Plausible use as anti cancer therapy for translocation Renal cell carcinoma (tRCC)

2023-07-06

Abstract excerpt

The TFE3 fusion gene, byproduct of Xp11.2 translocation, is the diagnostic marker for translocation renal cell carcinoma (tRCC). Absence of any clinically recognized therapy for tRCC, pressing a need to create novel and efficient therapeutic approaches. Previous studies shown that stabilization of the G-quadruplex structure in oncogenes suppresses their expression machinery. To combat the oncogenesis caused by fu...

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Literature Corpus work
4c9a40df-1bee-545f-ad04-56b64ddc3752
DOI
10.1101/2023.07.06.547934
Open publication

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Exploring G-quadruplex structure in <i>PRCC-TFE3</i> fusion Oncogene: Plausible use as anti cancer therapy for translocation Renal cell carcinoma (tRCC)DOI 10.1101/2023.07.06.547934
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