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Article

Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2012

Azad Abul Kalam, Bairati Isabelle, Samson Elodie, Cheng Dangxiao, Mirshams Maryam, Qiu Xin, Savas Sevtap, Waldron John, Wang Changshu, Goldstein David, Xu Wei, Meyer Francois, Liu Geoffrey

Abstract excerpt

PURPOSE: From the published literature, we identified 23 germ line sequence variants in 17 genes from hypothesis-generating studies that were associated with prognosis of head and neck cancer, including sequence variants of DNA repair (ERCC1, ERCC4, ERCC5, MSH2, XPA, ERCC2, XRCC1, XRCC3), DNA methylation (DNMT3B), cell cycle and proliferation (CCND1, TP53), xenobiotic metabolism (GSTM1, GSTT1, CYP2D6), metastatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to DNA, Neoplasm

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Share to Polymerase Chain Reaction

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Source

Identifiers

PMID: 22076708
DOI: 10.1158/1078-0432.CCR-11-1759

Genes

CTLA4
ERCC2
XRCC1
CCND1
ERCC1
ERCC4
ERCC5
FGFR4
GSTM1
GSTT1
MMP3
MSH2
XPA
XRCC3

Variants

rs231775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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