Article
The T393C polymorphism of GNAS1 as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum.
Cancer chemotherapy and pharmacology - 1 Jun 2012
Xie Fa-Jun, Zhao Peng, Kou Jun-Yan, Hong Wei, Fu Li, Hu Lin, Hong Dan, Su Dan, Gao Yun, Zhang Yi-Ping
Abstract excerpt
PURPOSE: The GNAS1 gene is linked to proapoptotic signaling and correlates closely with clinical outcomes in many human cancers. The aim of this study was to evaluate whether the T393C polymorphism of the GNAS1 gene could be used as a chemotherapy sensitivity and prognosis predictive marker of advanced non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum (GP). METHODS: In this study, we...
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