TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.

doi:10.1016/0092-8674(95)90480-8

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Article

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.

Cell - 8 Sept 1995

Morrow D M, Tagle D A, Shiloh Y, Collins F S, Hieter P

Abstract excerpt

Patients with the genetic disorder ataxia telangiectasia (AT) have mutations in the AT mutated (ATM) gene, which is homologous to TEL1 and the checkpoint gene MEC1. A tel1 deletion mutant, unlike a mec1 deletion, is viable and does not exhibit increased sensitivity to DNA-damaging agents. However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability...

Topics

Ataxia Telangiectasia
Base Sequence
Bleomycin
Cloning, Molecular
DNA Damage
Fungal Proteins
Gamma Rays
Genes, Fungal
Humans
Hydroxyurea
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Protein Serine-Threonine Kinases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 7545545
DOI: 10.1016/0092-8674(95)90480-8

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7545545-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.PMID 7545545Read ↗

The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells.Semantic proximity Read ↗

Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Semantic proximity Read ↗

TEL1 from Saccharomyces cerevisiae suppresses chromosome aberrations induced by ionizing radiation in ataxia-telangiectasia cells without affecting cell cycle checkpoints.Semantic proximity Read ↗

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response.Semantic proximity Read ↗

ATM function and telomere stability.Semantic proximity Read ↗

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Semantic proximity Read ↗

Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mec1 function in the DNA damage response does not require its interaction with Tel2.Semantic proximity Read ↗

Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia.Semantic proximity Read ↗

ATM: the product of the gene mutated in ataxia-telangiectasia.Semantic proximity Read ↗

<i>Drosophila</i> ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenanceSemantic proximity Read ↗

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