Article
Functional polymorphism of detoxification gene NQO1 predicts intensity of empirical treatment of childhood asthma.
Mutation research - 31 Mar 2009
Goodrich Geoffrey G, Goodman Philip H, Budhecha Sonia K, Pritsos Chris A
Abstract excerpt
The management of moderate to severe childhood asthma remains empirical. Genotypic variation has been proposed as a way to tailor specific pharmaceutical regimens to individual patients. The objective of this study was to determine the factors associated with asthma treatment progression, including functional polymorphisms of phase II detoxification enzymes, demographics, and environmental factors. In a study of...
Topics
- Age of Onset
- Anti-Asthmatic Agents
- Asthma
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Drug Resistance
- Female
- Genotype
- Humans
- Inactivation, Metabolic