Article
Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults.
Thorax - 1 Apr 2008
Imboden M, Rochat T, Brutsche M, Schindler C, Downs S H, Gerbase M W, Berger W, Probst-Hensch N M
Abstract excerpt
BACKGROUND: Bronchial hyperresponsiveness (BHR) and variation in glutathione S-transferase (GST) genes have been associated with asthma risk. The relationship of these two risk factors with adult onset asthma in the general population was investigated. METHODS: GSTP1 Ile105Val single nucleotide polymorphism and GSTM1 and GSTT1 gene deletion polymorphisms were genotyped in the population-representative SAPALDIA...
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