Article
Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City.
Thorax - 1 Jan 2004
Romieu I, Sienra-Monge J J, Ramírez-Aguilar M, Moreno-Macías H, Reyes-Ruiz N I, Estela del Río-Navarro B, Hernández-Avila M, London S J
Abstract excerpt
BACKGROUND: We recently reported that antioxidant supplementation with vitamins C and E mitigated ozone related decline in forced expiratory flow (FEF(25-75)) in 158 asthmatic children in an area with high ozone exposure in Mexico City. METHODS: A study was undertaken to determine whether deletion of glutathione S-transferase M1 (GSTM1 null genotype), a gene involved in response to oxidative stress, influences...
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