Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia.

Leukemia research - 1 Jul 2007

Barragan Eva, Collado Maria, Cervera Jose, Martin Guillermo, Bolufer Pascual, Roman Jose, Sanz Miguel A

Abstract excerpt

Functional polymorphisms in the genes encoding detoxification enzymes could modify the response to treatment in acute myeloid leukemia and therefore affect the final clinical outcome. In the present study, we genotyped 153 patients diagnosed with de novo acute myeloid leukemia (AML) to clarify the influence of the genetic polymorphisms CYP1A1*2A, CYP3A4*1B, CYP2E1*5B, del{GSTT1}, del{GSTM1}, and NQO1*2 on disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Cytochrome P-450 CYP1A1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2E1

Share to Cytochrome P-450 CYP3A

Share to Disease-Free Survival

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid

Share to NAD(P)H Dehydrogenase (Quinone)

Source

Identifiers

PMID: 17118447
DOI: 10.1016/j.leukres.2006.10.002

Genes

GSTM1
NQO1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia.PMID 17118447Read ↗

The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.Semantic proximity Read ↗

NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.Semantic proximity Read ↗

Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia.Semantic proximity Read ↗

Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias.Semantic proximity Read ↗

MDR-1 and GST polymorphisms are involved in myelodysplasia progression.Semantic proximity Read ↗

Influence of glutathione S‐transferases (GSTM1, GSTT1, and GSTP1) genetic polymorphisms and smoking on susceptibility risk of chronic myeloid leukemia and treatment responseSemantic proximity Read ↗

Glutathione S-transferase polymorphisms in children with myeloid leukemia: a Children's Cancer Group study.Semantic proximity Read ↗

The G⁵¹⁶T CYP2B6 germline polymorphism affects the risk of acute myeloid leukemia and is associated with specific chromosomal abnormalities.Semantic proximity Read ↗

CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication.Semantic proximity Read ↗

Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status.Semantic proximity Read ↗

Glutathione S-transferase gene polymorphisms and susceptibility to chronic myeloid leukemia.Semantic proximity Read ↗

Association of A(313)G glutathione S-transferase P1 germline polymorphism with susceptibility to de novo myelodysplastic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.