Point mutation of c-Ki-ras oncogene in gastric adenoma and adenocarcinoma with tubular differentiation.

doi:10.1111/j.1349-7006.1991.tb01847.x

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Article

Point mutation of c-Ki-ras oncogene in gastric adenoma and adenocarcinoma with tubular differentiation.

Japanese journal of cancer research : Gann - 1 Mar 1991

Kihana T, Tsuda H, Hirota T, Shimosato Y, Sakamoto H, Terada M, Hirohashi S

Abstract excerpt

The presence of point mutation at codons 12, 13 and 61 of the c-Ki-ras oncogene was investigated in 7 cases of gastric adenoma and 35 cases of gastric adenocarcinoma using DNA samples from formalin-fixed and paraffin-embedded tissues. Oligonucleotides encompassing the three codons were amplified by using the polymerase chain reaction (PCR), and then examined for point mutation by the selective oligonucleotide...

Topics

Adenocarcinoma
Adenoma
Aged
Amino Acid Sequence
Antisense Elements (Genetics)
Base Sequence
Cell Differentiation
Codon
Female
Genes, ras
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Oligonucleotide Probes

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 1902452
DOI: 10.1111/j.1349-7006.1991.tb01847.x
PMCID: PMC5918400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1902452-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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