Article
K-ras activation in gastric epithelial tumors in Japanese.
Cancer letters - 14 Jun 1991
Miki H, Ohmori M, Perantoni A O, Enomoto T
Abstract excerpt
Point mutation in codons 12, 13 and 61 of the K-ras oncogene in gastric epithelial tumors were investigated by polymerase chain reaction from sections of formalin-fixed, paraffin-embedded tissue followed by dot-blot hybridization with mutation-specific oligonucleotide probes. Point mutations were found specifically in four of 20 tumors of intestinal histological subtype; GGT to GAT in three cases and to GTT in...
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