Article
Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes.
Cancer - 15 Jul 1990
Kobayashi T, Tsuda H, Noguchi M, Hirohashi S, Shimosato Y, Goya T, Hayata Y
Abstract excerpt
The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in ten of 67 cases (15%). Microscopically, mutati...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Codon
- Female
- Genes, ras
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Staging