Article
Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes.
Cancer - 15 Jul 1990
Kobayashi T, Tsuda H, Noguchi M, Hirohashi S, Shimosato Y, Goya T, Hayata Y
Abstract excerpt
The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in ten of 67 cases (15%). Microscopically, mutation-positive cases revealed a tendency to be well differentiated (P less than 0.01). Especially, the incidence of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.