Article
Autosomal dominant Parkinson's disease and the route to new therapies.
Expert review of neurotherapeutics - 1 Jun 2007
Morris Huw R
Abstract excerpt
The pathogenesis of Parkinson's disease (PD) is not understood and there are currently no accepted disease modifying, neuroprotective treatments. There are two autosomal dominant PD genes, leucine-rich repeat kinase (LRRK)2 and alpha-synuclein. LRRK2 mutations are very common in patients with PD, accounting for 40% of patients with sporadic, nonfamilial disease in some ethnic groups. Alpha-synuclein mutations are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.