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Article

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Mar 2010

Taymans Jean-Marc, Cookson Mark R

Abstract excerpt

Parkinson's disease (PD) is generally sporadic but a number of genetic diseases have parkinsonism as a clinical feature. Two dominant genes, alpha-synuclein (SNCA) and leucine-rich repeat kinase 2 (LRRK2), are important for understanding inherited and sporadic PD. SNCA is a major component of pat...

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Source

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Identifiers

PMID: 20127702
DOI: 10.1002/bies.200900163
PMCID: PMC4662284

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20127702-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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