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Article

Genetic Perspective on the Relationship between Female Reproductive Traits, Exercise, and Bone Health Outcomes: Evidence from a National Database.

Lifestyle genomics - 1 Jan 2026

Chen Bo-Kai, Cambia Jansen Marcos, Shih Chien-An, Tsai Meng-Che

Abstract excerpt

INTRODUCTION: Female reproductive traits influence bone mineral density (BMD) and fracture risks through estrogen exposure. However, these causal relationships remain unclear due to confounding. Understanding these relationships is crucial for osteoporosis prevention strategies. This study aimed to investigate the causal impact of age at natural menopause (ANM) and age at menarche (AAM) on BMD and osteoporosis...

Topics

Humans
Female
Bone Density
Exercise
Menopause
Menarche
Osteoporosis
Taiwan
Middle Aged
Genetic Predisposition to Disease
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Genetic Risk Score

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Open in PubMed Open full text

Identifiers

PMID: 42430273
DOI: 10.1159/000553353
PMCID: PMC13472597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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