Article
The synchrony phenotype persists after elimination of multiple GATC sites from the dnaA promoter of Escherichia coli.
Journal of bacteriology - 1 Jun 2006
Wilkinson Terry G, Kedar G C, Lee Chi, Guzmán Elena C, Smith Douglas W, Zyskind Judith W
Abstract excerpt
To examine whether methylation of the GATC sites present in the dnaA promoter region is responsible for the strict temporal coordination of initiation events at oriC as measured by the synchrony of initiation, we introduced point mutations eliminating three (TGW1) and five (TGW2) of the six GATC sites present in the dnaA promoter region. All of the strains containing these mutations, including the one with five...
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