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Article

Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.

Pharmacogenomics - 1 Nov 2008

Baye Tes M, Zhang Yi, Smith Edward, Hillard Cecilia J, Gunnell Jennifer, Myklebust Joel, James Roland, Kissebah Ahmed H, Olivier Michael, Wilke Russell A

Abstract excerpt

AIMS: In humans, genetic variation in endocannabinergic signaling has been associated with anthropometric measures of obesity. In randomized trials, pharmacological blockade at the level of the cannabinoid receptor 1 (CNR1) receptor not only facilitates weight reduction, but also improves insulin sensitivity and clinical measures of lipid homeostasis. We therefore tested the hypothesis that genetic variation in...

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Source

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Identifiers

PMID: 19018721
DOI: 10.2217/14622416.9.11.1647
PMCID: PMC2784739

Genes

CNR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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