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Article

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.

Human molecular genetics - 1 Jul 2008

Benzinou Michael, Chèvre Jean-Claude, Ward Kirsten J, Lecoeur Cécile, Dina Christian, Lobbens Stephane, Durand Emmanuelle, Delplanque Jérome, Horber Fritz F, Heude Barbara, Balkau Beverley, Borch-Johnsen Knut, Jørgensen Torben, Hansen Torben, Pedersen Oluf, Meyre David, Froguel Philippe

Abstract excerpt

The therapeutic effects of cannabinoid receptor blockade on obesity-associated phenotypes underline the importance of the endocannabinoid pathway on the energy balance. Using a staged-approach, we examined the contribution of the endocannabinoid receptor 1 gene (CNR1) on obesity and body mass ind...

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Source

Identifiers

PMID: 18375449
DOI: 10.1093/hmg/ddn089

Genes

CNR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18375449-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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