Article
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.
Human molecular genetics - 1 Jul 2008
Benzinou Michael, Chèvre Jean-Claude, Ward Kirsten J, Lecoeur Cécile, Dina Christian, Lobbens Stephane, Durand Emmanuelle, Delplanque Jérome, Horber Fritz F, Heude Barbara, Balkau Beverley, Borch-Johnsen Knut, Jørgensen Torben, Hansen Torben, Pedersen Oluf, Meyre David, Froguel Philippe
Abstract excerpt
The therapeutic effects of cannabinoid receptor blockade on obesity-associated phenotypes underline the importance of the endocannabinoid pathway on the energy balance. Using a staged-approach, we examined the contribution of the endocannabinoid receptor 1 gene (CNR1) on obesity and body mass index (BMI) in the European population. With the input of CNR1 exons and 3' and 5' regions sequencing and HapMap database,...
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