Article
Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men.
The Journal of clinical endocrinology and metabolism - 1 Jun 2007
Russo Paola, Strazzullo Pasquale, Cappuccio Francesco P, Tregouet David A, Lauria Fabio, Loguercio Maria, Barba Gianvincenzo, Versiero Marco, Siani Alfonso
Abstract excerpt
CONTEXT: The endocannabinoid system modulates food intake and body weight in animal models. Treatment with the cannabinoid type 1 receptor blocker, rimonabant, reduces body weight in obese individuals. OBJECTIVE: The aim of this study was to determine whether single nucleotide polymorphisms of the gene encoding cannabinoid type 1 receptor, CNR1, are associated with body fat mass and distribution in two...
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