Article
A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain.
PloS one - 31 Dec 2010
Feng Qiping, Jiang Lan, Berg Richard L, Antonik Melissa, MacKinney Erin, Gunnell-Santoro Jennifer, McCarty Catherine A, Wilke Russell A
Abstract excerpt
We have previously shown that genetic variability in CNR1 is associated with low HDL dyslipidemia in a multigenerational obesity study cohort of Northern European descent (209 families, median = 10 individuals per pedigree). In order to assess the impact of CNR1 variability on the development of dyslipidemia in the community, we genotyped this locus in all subjects with class III obesity (body mass index >40...
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