Article
Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution.
European journal of endocrinology - 1 Sept 2010
Frost M, Nielsen T L, Wraae K, Hagen C, Piters E, Beckers S, De Freitas F, Brixen K, Van Hul W, Andersen M
Abstract excerpt
OBJECTIVE: Both animal and human studies have associated the endocannabinoid system with obesity and markers of metabolic dysfunction. Blockade of the cannabinoid receptor 1 (CB1) caused weight loss and reduction in waist size in both obese and type II diabetics. Recent studies on common variants of the CB1 receptor gene (CNR1) and the link to obesity have been conflicting. The aim of the present study was to...
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