Article
A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.
European journal of obstetrics, gynecology, and reproductive biology - 1 Mar 2011
Bienertova-Vasku Julie, Bienert Petr, Dostalova Zuzana, Chovanec Josef, Vasku Anna, Vasku Vladimir
Abstract excerpt
OBJECTIVE: Recently it has been proposed that tightly regulated levels of endogenous cannabinoids play a fundamental role in early placental development. The aim of this study was to investigate associations of three single-nucleotide polymorphisms (SNPs) in the cannabinoid 1 receptor (CNR1) gene (rs1049353, rs12720071 and rs806368) and their inferred haplotypes with pre-eclampsia, a severe pregnancy-associated...
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