A common functional promoter variant links CNR1 gene expression to HDL cholesterol level.

doi:10.1038/ncomms2973

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Article

A common functional promoter variant links CNR1 gene expression to HDL cholesterol level.

Nature communications - 1 Jan 2013

Feng Q, Vickers K C, Anderson M P, Levin M G, Chen W, Harrison D G, Wilke R A

Abstract excerpt

Type 1 cannabinoid receptor blockers increase high-density lipoprotein cholesterol levels. Although genetic variation in the type 1 cannabinoid receptor--encoded by the CNR1 gene--is known to influence high-density lipoprotein cholesterol level as well, human studies conducted to date have been limited to genetic markers such as haplotype-tagging single nucleotide polymorphisms. Here we identify rs806371 in the...

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PMID: 23748922
DOI: 10.1038/ncomms2973
PMCID: PMC3873874

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CNR1

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