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Article

Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?

Biochimica et biophysica acta - 1 Feb 2009

Hong Dong-Pyo, Fink Anthony L, Uversky Vladimir N

Abstract excerpt

alpha-synuclein is a small presynaptic protein (14,460 D) that is abundantly distributed in the brain. Although, its function is unknown, the aggregated form of alpha-synuclein is a pathological hallmark of several neurodegenerative diseases, including Parkinson's disease (PD). Epidemiological studies have shown that smoking can lessen the incidence of Parkinson's disease, indicating that smoke may contain...

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PMID: 19013262
DOI: 10.1016/j.bbapap.2008.09.026
PMCID: PMC2647853

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AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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