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Cross‐seeding effects of amyloid β‐protein and α‐synuclein

27 Jun 2012

Abstract excerpt

Amyloid β-protein (Aβ) and α-synuclein (αS) are the primary components of amyloid plaques and Lewy bodies (LBs), respectively. Previous in vitro and in vivo studies have suggested that interactions between Aβ and αS are involved in the pathogenesis of Alzheimer's disease and LB diseases. However, the seeding effects of their aggregates on their aggregation pathways are not completely clear. To investigate the...

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PMID: 22734715
DOI: 10.1111/j.1471-4159.2012.07847.x

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