Article

Nicotine Ameliorates <i>α</i> -synuclein Pre-formed Fibril-Induced Behavioral Deficits and Pathological Features in Mice

2024-05-10

Abstract excerpt

<h4>Background</h4> Epidemiologic study suggests nicotine reduces risk of PD, could be potential treatment for Parkinson’s disease. <h4>Objective</h4> To study the effect of nicotine on behavioral phenotypes and pathological characteristics of mice induced by human alpha-synuclein preformed fibers (α-syn-PFF). <h4>Methods</h4> Mice were injected with 5 μg of human α-syn-PFF in the hippocampus while administerin...

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Literature Corpus work: c618389a-c18b-5e27-9347-ba43388a3ef5
DOI: 10.1101/2024.05.09.593280

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