Article

Alpha-Synuclein at the Interface between Depression, Parkinson’s Disease and Dementia: Evidence from Epidemiology, Population Genetics and Gene-Environment Interactions

2022-09-14

Abstract excerpt

Parkinson’s disease and Alzheimer’s disease are the most commonly diagnosed neurodegenerative disorders. Though these disorders differ in terms of their underlying pathophysiology as well as in their clinical features and course, there is a certain degree of overlap between them. This overlap may be partly related to α-synuclein-mediated neuropathological changes. Recent evidence has found that d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d7fd853-149a-59de-8f36-adefba713fa9
DOI: 10.20944/preprints202209.0197.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alpha-Synuclein at the Interface between Depression, Parkinson’s Disease and Dementia: Evidence from Epidemiology, Population Genetics and Gene-Environment InteractionsDOI 10.20944/preprints202209.0197.v1Read

Variants in SNCA Gene Are Associated with Parkinson’s Disease Risk and Cognitive Symptoms in a Brazilian SampleSemantic proximity Read

Age-Environment and Gene-Environment Interactions in the Pathogenesis of Parkinson's DiseaseSemantic proximity Read

Metal Exposure and SNCA rs356219 Polymorphism Associated With Parkinson Disease and ParkinsonismSemantic proximity Read

Health phenome of Parkinson’s patients reveals prominent mood-sleep clusterSemantic proximity Read

α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson’s DiseaseSemantic proximity Read

Environmental-Genetic Interactions in the Pathogenesis of Parkinson's DiseaseSemantic proximity Read

Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson's Disease in the Province of Brescia, Italy.Semantic proximity Read

α-syn and SNP rs356219 as a potential biomarker in blood for Parkinson's disease in Mexican Mestizos.Semantic proximity Read

Association between gene polymorphism and depression in Parkinson's disease: A case-control study.Semantic proximity Read

Familial α-synucleinopathy spectrum features in patients with psychiatric REM sleep behaviour disorder.Semantic proximity Read

Alpha‐synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and diseaseSemantic proximity Read

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s diseaseSemantic proximity Read