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Article

The effect of tyrosine residues on α-synuclein fibrillation.

Acta chimica Slovenica - 1 Jan 2015

Pirc Katja, Škarabot Miha, Pogačnik Lea, Žerovnik Eva, Poklar-Ulrih Nataša

Abstract excerpt

Aggregation of the intrinsically disordered protein α-synuclein into ordered amyloid fibrils is implicated in the pathogenesis of Parkinson's disease. To unravel the role of Tyr residues in α-synuclein fibrillation, we prepared recombinant N-terminal (Y39A) and C-terminal (Y(125,133,136)A) mutants of α-synuclein and examined their fibrillation propensities by thioflavin T and 1-anilinonaphthalene-8-sulfonate...

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PMID: 25830974
DOI: 10.17344/acsi.2014.882

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SDS

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