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Article

Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy.

The Journal of biological chemistry - 19 Jan 2018

Flynn Jessica D, McGlinchey Ryan P, Walker Robert L, Lee Jennifer C

Abstract excerpt

Parkinson's disease (PD) is associated with the formation of α-synuclein amyloid fibrils. Elucidating the role of these β-sheet-rich fibrils in disease progression is crucial; however, collecting detailed structural information on amyloids is inherently difficult because of their insoluble, non-crystalline, and polymorphic nature. Here, we show that Raman spectroscopy is a facile technique for characterizing...

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Identifiers

PMID: 29191831
DOI: 10.1074/jbc.M117.812388
PMCID: PMC5777252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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