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Article

Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models.

Gene - 5 Oct 2021

Inoue Eiji, Suzuki Takahiro, Shimizu Yasuharu, Sudo Keiichi, Kawasaki Haruhisa, Ishida Norio

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the brain. α-Synuclein is an aggregation-prone neural protein that plays a role in the pathogenesis of PD. In our previous paper, we found that saffron; the stigma of Crocus sativus Linné (Iridaceae), and its constituents (crocin and crocetin) suppressed aggregation of α-synuclein and...

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Identifiers

PMID: 34224829
DOI: 10.1016/j.gene.2021.145811

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