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Article

Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Gelman Simon, Palma Jonathan, Tombaugh Geoffrey, Ghavami Afshin

Abstract excerpt

Genetically modified mice have provided insights into the progression and pathology of Alzheimer's disease (AD). Here, we have examined two mouse models of AD: the rTg4510 mouse, which overexpresses mutant human Tau gene, and the APP/PS1 mouse, which overexpresses mutant human genes for amyloid precursor protein and presenilin 1. Both models exhibit deficits in hippocampal function, but comparative analyses of...

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Identifiers

PMID: 29154272
DOI: 10.3233/JAD-170457
PMCID: PMC5836403

Genes

APP

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