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Article

Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.

Experimental neurology - 1 Jan 2010

Lim Youngshin, Kehm Vicky M, Li Chi, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Transgenic (Tg) mouse models of Parkinson's disease (PD) generated to date have primarily been designed to overexpress human alpha-synuclein (alpha-syn) to recapitulate PD-like motor impairments as well as PD-like nigrostriatal degeneration and alpha-syn pathology. However, cognitive impairments and cortical alpha-syn pathology are also common in PD patients. To model these features of PD, we created...

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Identifiers

PMID: 19833127
DOI: 10.1016/j.expneurol.2009.10.005
PMCID: PMC2812632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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