Article
Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.
Experimental neurology - 1 Jan 2010
Lim Youngshin, Kehm Vicky M, Li Chi, Trojanowski John Q, Lee Virginia M-Y
Abstract excerpt
Transgenic (Tg) mouse models of Parkinson's disease (PD) generated to date have primarily been designed to overexpress human alpha-synuclein (alpha-syn) to recapitulate PD-like motor impairments as well as PD-like nigrostriatal degeneration and alpha-syn pathology. However, cognitive impairments and cortical alpha-syn pathology are also common in PD patients. To model these features of PD, we created...
Topics
- Age Factors
- Animals
- Animals, Newborn
- Axons
- Cell Death
- Cell Proliferation
- Disease Models, Animal
- Doxycycline
- Gene Expression Regulation, Developmental
- Hippocampus
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins