Article
Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.
PloS one - 1 Jan 2013
Paumier Katrina L, Sukoff Rizzo Stacey J, Berger Zdenek, Chen Yi, Gonzales Cathleen, Kaftan Edward, Li Li, Lotarski Susan, Monaghan Michael, Shen Wei, Stolyar Polina, Vasilyev Dmytro, Zaleska Margaret, D Hirst Warren, Dunlop John
Abstract excerpt
Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal inclusions called Lewy bodies, which are comprised of alpha-synuclein (α-syn). Duplication, triplication or genetic mutations in α-syn (A53T, A30P and E46K) are linked to autosomal dominant PD; thus implicating its role in the pathogenesis of PD. In both PD patients and mouse models, there is increasing evidence that neuronal...
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