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Article

Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein.

Neurobiology of disease - 1 Feb 2021

Tweedy Clare, Kindred Nathan, Curry Joshua, Williams Christopher, Taylor John-Paul, Atkinson Peter, Randall Fiona, Erskine Daniel, Morris Christopheer M, Reeve Amy K, Clowry Gavin J, LeBeau Fiona E N

Abstract excerpt

Abnormal excitability in cortical networks has been reported in patients and animal models of Alzheimer's disease (AD), and other neurodegenerative conditions. Whether hyperexcitability is a core feature of alpha(α)-synucleinopathies, including dementia with Lewy bodies (DLB) is unclear. To assess this, we used two murine models of DLB that express either human mutant α-synuclein (α-syn) the hA30P, or human...

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Identifiers

PMID: 33347975
DOI: 10.1016/j.nbd.2020.105226
PMCID: PMC7859835

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