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Article

Incorporation of 3’-Azido-3’-deoxythymidine into Cellular DNA and Its Removal in a Human Leukemic Cell Line

1 Jan 1990

Abstract excerpt

3'-Azido-3'-deoxythymidine (AZT) is currently used in the treatment of patients with the acquired immunodeficiency syndrome (AIDS); this often, however, results in hematological toxicity. Although the mechanism of toxicity is not clear, it is thought to result in part from incorporation of AZT into DNA, which causes chain termination. In order to investigate the mechanism of AZT toxicity, the relationship between...

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Identifiers

PMID: 2369551
DOI: 10.3727/095535490820874740

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